trilostane for dogs cushings - PETS
Trilostane (Vetoryl) is a commonly prescribed FDA-approved treatment for Cushing’s disease in dogs. Cushing’s disease causes your dog’s adrenal glands to produce too much cortisol. Most often this is due to a tumor that affects the adrenal glands.
Understanding the Context
Trilostane is used to lower excess stress hormone levels released by the adrenal glands due to a condition known as hyperadrenocorticism (also known as Cushing’s disease) in dogs and sometimes in cats. The News-Gazette: Pet Talk | When aging isn’t the answer: Cushing’s disease in dogs Pet Talk | When aging isn’t the answer: Cushing’s disease in dogs VETORYL ® Capsules are indicated for the treatment of pituitary-dependent and adrenal-dependent hyperadrenocorticism in dogs. As with all drugs, side effects may occur. Trilostane is not an aromatase inhibitor and hence does not inhibit the conversion of androgens like androstenedione and testosterone into estrogens like estrone and estradiol.
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Key Insights
[1] However, trilostane may nonetheless inhibit estrogen synthesis by inhibiting androgen synthesis. [1] Trilostane is a treatment for hyperadrenocorticism (Cushing’s Disease) and Alopecia X. It is given by mouth as a capsule, given with food. Common side effects include lethargy, vomiting, diarrhea, and anorexia. It is contraindicated in liver or kidney disease and pregnant animals.
Final Thoughts
The active ingredient in Vetoryl is an enzyme inhibitor called trilostane, which blocks the excessive production of cortisol by the adrenal glands. Vetoryl is currently available in 5 mg, 10 mg, 20 mg, 30 mg, 60 mg, and 120 mg capsules.